TGF-β3 regulates cell proliferation, growth, differentiation, and motility. It is involved in adipogenesis, chondrogenesis, embryogenesis, tissue remodeling, wound healing and tumor formation. Recent data suggest that individual TGF-β isoforms (TGF-β1, β2 and β3) have overlapping yet distinct biological actions and target cell specificities, both in developing and adult tissues. TGF-β3 is a new isoform of the TGF beta superfamily and is presumed to play an important role in wound repair and scarring. TGF-β3 is believed to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis. rHu TGFβ3 produced in E. coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain that contains 112 amino acids each, and has a total molecular mass of 25.5 kDa.