Chemerin is thought to act as a cell surface receptor. It has been found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Additionally, it has been implicated in autocrine/paracrine signaling for adipocyte differentiation and stimulation of lipolysis. Chemerin is a ligand for the G-protein coupled receptor known as ChemR23 (or chemokine-like receptor-1), which is expressed mainly on dendritic cells, macrophages and some adipocytes. Recombinant human Chemerin expressed in E. coli is a non-glycosylated protein containing 138 amino acids and having a total molecular mass of 16 kDa.