PDGF-AB functions as a mitogenic factor, and is involved in hyperplasia, cell migration, embryonic neuron development, and angiogenesis. PDGF is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication. rHu PDGF-AB produced in E. coli is a heterodimeric, non-glycosylated, polypeptide chain that contains 234 amino acids consists of a 14.3 kDa alpha-chain and a 12.1 kDa beta-chain, and has a total molecular mass of 26.4 kDa.