PDGF-BB functions as a mitogenic factor, and is involved in hyperplasia, cell migration, embryonic neuron development, and angiogenesis. PDGF is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication. rHu PDGF-BB expressed in E. coli is a homodimeric, non-glycosylated, polypeptide chain that contains two 109 amino acid chains and has a molecular mass of 24.3 kDa.
Recombinant Human PDGF-BB, produced in yeast, is a double, glycosylated polypeptide chain containing 109 amino acids with a molecular mass of approximately 32 Kda.