| 产品名称 | TBK1, GST-tag |
| 产品货号 | 40286 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 110 kDa
Genbank #: NM_013254
Tag(s): N-terminal GST-tag
a.a: 2-729 (end)
Background: TBK1, also known as NAK or NFkB-activating kinase, is an upstream protein kinase that can phosphorylate and activate the IkB kinases (1). Activation of IkB kinases allows the phosphorylation of IkB protein which is then degraded via the ubiquitination pathway. This mechanism allows the activation of the NFkB transcriptional complex. TBK1 is a specific upstream regulator of IkB kinases and can also interact and the IkB protein TANK. TBK1 is a component of the virus-activated kinase that phosphorylate IRF3 and IRF7 allowing their dimerization and translocation to the nucleus, where they induce transcription of interferon (2).
Description: Recombinant human TBK1, also known as NF-kappa-B-activating kinase, T2K, and TANK-binding kinase 1, with N-terminal GST-tag, 2-729 (end), Genbank accession number NM_013254, expressed in Sf9 insect cells via a baculovirus expression system. MW=110 kDa.
Synonym(s): NAK, T2K, FLJ11330, TBK,Serine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1, FTDALS4, NAK
Purity: ≥90%
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween20, 8.8mM glutathione, 20% glycerol
Format: Aqueous buffer solution
Storage / Stability: At least 6 months at –80°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Tojima, Y. et al: NAK is an I-kappa-B kinase-activating kinase. Nature 404: 778-782, 2000.
2. Sharma, S. et al: Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148-1151, 2003. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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