| 产品名称 | FKBP12, His-tag - Proteins - Other Proteins |
| 产品货号 | 40550 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 200 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 13.1 kDa
Genbank #: NM_054014
Tag(s): N-terminal His-tag
a.a: full length
Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity.
Description: Human FKBP12 (FK506 binding protein 1A, transcript variant 12A), GenBank Accession No. NM_054014, full length with N-terminal His-tag, MW= 13.1 kDa, expressed in an E. coli expression system. 5References: 1. Knappe,T.A. et al., J. Mol. Biol. 368 (5), 1458-1468 (2007). 2. Wear,M.A. et al., Protein Expr. Purif. 51 (1), 80-95 (2007).
Synonym(s): FK506 Binding Protein 1, FKBP, Rotamase, Immunophilin FKBP12, PPIase, Calstabin
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 50% glycerol.
Format: Aqueous buffer solution
Application(s): Useful for testing rapamycin inhibition of mTOR.
Reference(s): 1. Knappe,T.A. et al., J. Mol. Biol. 368 (5),
1458-1468 (2007). Application Reference:
Warning(s): Avoid freeze/thaw cycles
Scientific Category: Miscellaneous
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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