| 产品名称 | RbBP5, His-tag |
| 产品货号 | 71202 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 60 kDa
Genbank #: NM_005057
Tag(s): N-terminal His-tag
a.a: 2–538 (end)
Background: RbBP5 binds directly to retinoblastoma protein, which regulates cell proliferation. It
interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. In embryonic stem (ES) cells, RbBP5 plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3Lys4 methylation at key developmental loci, including that
mediated by retinoic acid. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys4 of histone H3.
Description: Human retinoblastoma binding protein 5 (RbBP5), GenBank Accession No. NM_005057, a.a. 2 – 538 (end) with N-terminal His-tag, MW= 60 kDa, expressed in an E. coli expression system.
UniProt Q15291
Synonym(s): Rbbp5, retinoblastoma binding protein 5, Set1c WD40 Repeat Protein, SWD1, RBQ3
Formulation: 20 mM Tris-HCl, pH 7.4, 300 mM NaCl, 10% glycerol, 1 mM TCEP, and 1 µM ZnCl2
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Cao, F., et al., PLoS One. 2012 Nov 23; 5(11): e14102.
2. Odho, Z., et al., J Biol Chem. 2010 Oct 22; 285(43): 32967-76. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Miscellaneous
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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