Inhibits the p53-MDM2 interaction (20 μM). Inhibits U2Os cell growth (EC50=10 μM). Has also been shown to inhibit bovine chymotrypsin A-gamma.

ZPCK; N–Benzyloxycarbonyl–L–phenylalaninylchloromethyl ketone

>98% by TLC.

Soluble in DMSO (50 mg/ml) or ethanol (15 mg/ml) with heating

White crystalline solid

Useful for the inhibition of p53-MDM2 interactions.

Li J. et al. A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction. J. Biomol. Screening 2011 16:450.

Protect from moisture.

Ubiquitin Enzymes

Inhibitors/Activators