| 产品名称 | UBE2D2, His-Tag |
| 产品货号 | 79370 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 20 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Xenopus
Host Species: E. coli
MW: 17 kDa
Genbank #: NM_001093036
Tag(s): N-Terminal His-Tag
Background: UBE2D2(UBC4) Protein or ubiquitin-conjugating enzyme E2D2 is a member of the E2 ubiquitin-conjugating enzyme family which functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. UBE2D2 specifically ubiquitinates E6AP and in vivo inhibition of UBE2D2 can lead to inhibition of E6-stimulated p53 degradation (1). UBE2D2 could conjugate ubiquitin to target proteins in an E6AP-dependent manner.
Description: Recombinant full-length Xenopus UBE2D2, also known as UBC4, PUBC1, UBC4/5, UBCH5B, and E2(17)KB2. Genbank Accession No. NM_001093036, with an N-terminal His-tag, expressed in E. Coli cells. MW=17 kDa.
Synonym(s): UBC4, PUBC1, UBC4/5, UBCH5B, E2(17)KB2
Formulation: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, and 25% glycerol.
Storage / Stability: At least 6 months at –70°C. Avoid freeze/thaw cycles. Application(s): Useful for the study of ubiquitin enzyme kinetics, and as a positive control for Western blot studies.
Reference(s): 1. Mondal, S., et al., Anal. Biochem. 2016; 510: 41-51. 2. Rolfe, M., et al., Proc. Nat. Acad. Sci. 1995; 92: 3264-3268. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Ubiquitination
Product Type: Activating Enzyme
Data shown is lot-specific. Contact us for specific information on other lots.
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