A potent and selective inhibitor of ubiquitin C-terminal hydrolase L3 (UCH-L3) (IC50 = 0.6 µM). Inhibits ubiquitin C-terminal hydrolase L1 (UCH-L1) only at higher concentrations (IC50 = 75 µM).

4,5,6,7–tetrachloro–1H–indene–1,3(2H)–dione

≥97% by TLC.

Soluble in DMSO (25 mg/ml)

White powder

Useful for cell-based and in vitro studies of UCH-L3 function.

1. Love, K.R. et al. Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat. Chem. Biol. 2007. 3:697.
2. Mtango, N.R. et al. Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation. J. Cell Physiol. 2012. 227:2022.

Protect from moisture.

Ubiquitin Enzymes

Inhibitors/Activators