Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. Cell permeable. Significant inhibition is typically seen at 30-100 μM.

9H–Indeno[1,2–e][1,2,5]oxadiazolo[3,4–b]pyrazin–9–one

>98% by TLC.

Soluble in DMSO (up to 20 mg/ml, with heating)

Yellow powder

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.

Useful for the inhibition of SCFMET30 in cell-based or in vitro assays.

Aghajanyy, M. et al. Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat. Biotech. 2010, 28(7):738.

Protect from moisture.

Ubiquitin Enzymes

Inhibitors/Activators