| 产品名称 | SENP6 Core Domain, His-tag |
| 产品货号 | 81097 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 25 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 55 kDa
Tag(s): His-tag
Background: SENP6 is a SUMO/sentrin specific protease that functions to remove SUMO from conjugated proteins. SENP6 has been shown to deSUMOylate a member of the ligand-activated transcription factores called retinoid X receptor alpha. The transcriptional activity of RXRalpha is regulated by SUMOylation. Researchers have demonstrated that SENP6 has a preference for SUMO2/3 conjugates over SUMO1 conjugates.
Description: Human SENP6 Core Domain recombinant protein, with His-tag, expressed in E. coli.
UniProt Q9GZR1
Synonym(s): FKSG6, FLJ11355, FLJ11887, KIAA0389, KIAA0797, Sentrin/SUMO-specific protease SENP6, Sentrin-specific protease 6, SSP1, SUMO-1-specific protease 1, SUSP1
Format: Aqueous buffer solution
Storage / Stability: Store at or below –80°C. Stable as supplied for up to 1 year when stored dessicated at –80°C. Application(s): This enzyme is active in the SUMO3-CHOP assay.
Reference(s): 1. Choi, S.J. et al. Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J. Biol. Chem. 2006. 281(41):30669-77.
2. Mukhopadhyay D. et al. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J. Cell Biol. 2006 Sep 25;174(7):939-49. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Ubiquitination (SUMOylation)
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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