NSC 632839 hydrochloride is an inhibitor of USP (ubiquitin isopeptidase) activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation.

3,5–Bis[(4–methylphenyl)methylene]–4–piperidone hydrochloride

>98% by HPLC.

Soluble in DMSO (8 mg/ml)

Yellow powder

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.

Useful for non-specific inhibition of ubiquitin-like isopeptidases for cell biology and drug discovery studies.

1. Aleo, E. et al. Identification of New Compounds That Trigger Apoptosome-Independent Caspase Activation and Apoptosis. Cancer Res. 2006. 66:9235.
2. Nicholson, B. et al. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci. 2008. 17:1035

Protect from moisture.

Ubiquitin Enzymes

Inhibitors/Activators