| 产品名称 | TC-PTP(PTPN2), GST-tag |
| 产品货号 | 30013 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 20 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 62.3 kDa
Genbank #: BC016727
Tag(s): N-terminal GST-tag
a.a: 2–315
Background: Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.
Description: Human recombinant TC-PTP, also known as PTPN2 (protein tyrosine phosphatase N2), Genbank accession No. BC016727, a.a. 2-315 (catalytic domain), with N-terminal GST tag, MW=62.3 kDa, expressed in an E. coli expression system.
Synonym(s): PTPN2, TC-PTP, PTPT, TCELLPTP, TCPTP
Specific Activity: 463 pmole/min/µg
Unit Definition: One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Assay Conditions: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP.
Formulation: 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Format: Aqueous buffer solution
Storage / Stability: >12 months at -80°C. Application(s): Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Reference(s): 1. N.F. Zander et al., Biochemistry 1991, 30: 6964.
2. D.E. Cool et al., Proc. Natl. Acad. Sci. USA 86: 5257. Warning(s): Avoid freeze/thaw cycles
Scientific Category: PTP/Non-rec.
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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