The fluorogenic Cathepsin V substrate is a Z-Leu-Arg-AMC dipeptide. It can be used as a substrate for activity assays of Cathepsins B, K, L, S, and V. λex 353-380 nm, λem=440-460 nm

Z-Leu-Arg-AMC, Z-LR-AMC, Benzyloxycarbonyl- L-leucyl- L-arginine 4-methylcoumaryl-7-amide

5 mM solution in DMSO (10 µl)

5 mM

DMSO solution

Stable at least 6 months from date of receipt, when stored as directed

Useful for the study of cathepsin activity, and for screening small molecule inhibitors of cathepsins B, K, L, S, and V for drug discovery and HTS applications.

1. Fonovic, M. et al., Biol Chem 385(6), 505-509 (2004).
2. D. Broemme, et al. J. Biol. Chem., 271, 2126 (1996).

Can also be used as a substrate for human tissue kallikrein, and the falcipains I - III, the hemoglobin-degrading cysteine proteases from the malaria parasite Plasmodium falciparum .

Protect from direct exposure to light. Avoid freeze/thaw cycles.

Protease

Substrate