Zaprinast is a cGMP-specific PDE inhibitor which moderately inhibits PDE5 and PDE6. It weakly inhibits PDE9, PDE10 and PDE11. Sildenafil (Viagra™) was developed from Zaprinast, which enhances the vasodilatory effects of nitric oxide in a range of vascular tissues by prolonging the cGMP-mediated activation of cGMP-dependent protein kinase. Also, GPR35 is activated by Zaprinast.
| 产品名称 | Zaprinast - Inhibitors / Activators - Phosphodiesterase(s) |
| 产品货号 | 27218 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 271.3 Da
CAS Registry #: 37762-06-4
Formula: C13H13N5O2
Description: Purity: ≥98% by HPLC Biological Activity: Zaprinast inhibits PDE5 and PDE6 with IC50 values of 0.5-0.76 µM and
0.15 µM, respectively.
Solubility: Soluble in DMSO and DMF, purged with an inert gas. Solubility in DMSO and DMF
is ~10 mg/ml. For maximum solubility, dissolve in DMF and then dilute with the aqueous buffer
of choice.
Format: A crystalline solid.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Nakamizo, T., et al., J. Neurosci. Res. 2003;71:485-495.
2. Gibson, A., et al., Eur. J. Pharmacol. 2001;411:1-10. 3. Taniguchi, Y., et al., FEBS Lett. 2006;580:5003-5008. Scientific Category: PDE
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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