Vinpocetine, also known as Cavinton or ethyl apovincaminate, is a specific inhibitor of basal and calmodulin-activated PDE1. Also blocks voltage-gated Na+ channels.

Cavinton; ethyl apovincaminate; Vinpocetin;

Vinpocetine is selective for PDE1: IC50 = 21 µM, vs. PDE3: IC50 = 300 µM (bovine heart). Vinpocetine inhibits differently the various subtypes of PDE1 (IC50 from 8 to 50 µm). It is also reported to inhibit PDE7B with an IC50 of 60 µM, and it can have effects on Heat Shock Factor 1 (EC5050 = 195 µM) and ADH-induced lipid peroxidation ( IC50 = 137 µM in rat brain microsome).

Soluble in ethanol up to 50 mM or DMSO at 5 mg/ml

white solid

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Photosensitive; protect from light.

PDE Inhibitor

Inhibitor