Quercetin is an inhibitor of PDEs of both cAMP and cGMP. It is a flavonoid found in plant and fruit bark or rinds. It is estimated that normal dietary intake of Quercetin for humans is 0.1-0.2 mg/kg. Quercetin can induce renal adenomas in male rats when fed at 2,000 mg/kg.

≥95% by HPLC

Quercetin has been shown to inhibit PDE 5A with an IC50 value of 1.9 µM.

Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in ethanol is 2 mg/ml and solubility in DMSO and DMF is 30 mg/ml.

A crystalline solid.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Gschwendt, M., et al., Biochem. Biophys. Res. Commun. 1983; 117(2): 444-447.
2. Young, J.F., et al., Am. J. Clin. Nutr. 1999; 69(1): 87-94.

PDE

Inhibitor