| 产品名称 | S- (+)-Rolipram |
| 产品货号 | 27648-3 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 275.3 Da
CAS Registry #: 85416-73-5
Formula: C16H21NO3
Target: PDE4B
Background: Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S-(+)-Rolipram enantiomer is 2-10x less potent than the R-(-)-Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.
Description: S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.
Synonym(s): (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Schneider et al (1986). Eur.J.Pharmacol. 127 105.
2. Owens et al (1997). Biochem.J. 326 53. 3. Ohsawa et al (1998). Jpn.J.Pharmacol. 77 147. Scientific Category: PDE Inhibitor
Product Type: Inhibitor
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