| 产品名称 | Histone H4 peptide (1-21), Dimethyl R3, Biotin-labeled - Substrates - Methyltransferase(s) |
| 产品货号 | 51200 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 500 µl |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 2630.14 Da
Genbank #: NM_003548
Tag(s): Biotin
a.a: 1–21
Background: Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. PRMT1 is the primary methyltransferase that deposits the ADMA mark, and it accounts for over 90% of this type of methylation. The Arg3 residue of Histone H4 is a target for PRMT1 methylation. Methylation of histone H4 at Arg3 is an important step in transcriptional activation, and allows for subsequent acetylation of H4 tails by p300.
Description: Biotinylated histone H4 peptide (a.a. 1-21) asymmetrically di-methylated at Arginine 3. It also contains a C-terminal GG linker, followed by a biotinylated Lys.
UniProt P62805
Synonym(s): H4R3me2a, Histone H4 Arg3me2 asymmetric
Purity: ≥95% by HPLC
Supplied As: 200 µM solution in water (500 µl)
Format: Aqueous buffer solution
Storage / Stability: ≥ 6 months at -20°C or -70°C Application(s): Useful as a positive control for type I protein arginine methyltransferases (PRMTs) and or as a substrate for JMJD6 arginine demethylase in drug discovery and HTS applications.
Warning(s): Avoid freeze/thaw cycles.
Amino Acid Sequence: SG-R(Me2a)-GKGGKGLGKGGAKRHRKVGG-K(Biotin)
Scientific Category: Methyltransferase
Product Type: Substrate
Data shown is lot-specific. Contact us for specific information on other lots.
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