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产品名称 Histone H4 peptide (1-21) - Substrates - Methyltransferase(s)
产品货号 52014
产品价格 现货询价，电话：010-67529703
产品规格 160 nmole
产品品牌 bpsbioscience
产品概述
产品详情
MW: 2091.5 Da
Genbank #: NM_003548
Tag(s): none
a.a: 1–21
Background:
Histone acetyltransferase (HAT) p300/CBP catalyses the acetylation of this N-terminal tail of free histone H4 at Lys5, 8, 12, 16. Lys8 is thought to be the preferred acetylation site in H4. A number of methyltransferases also modify this region of the histone.
Description:
A peptide substrate for Histone 4 R3 methyltransferases. The peptide corresponds to amino acid residues 1-21 of histone H4.
UniProt
P62805
Synonym(s):
H4, HIST4, Histone h4
Purity:
≥95% by HPLC
Supplied As:
800 µM solution in water (200 µl)
Format:
aqueous solution
Storage / Stability:

≥ 12 months at -20°C or -70°C

Application(s):
Useful as a substrate for histone methyltransferase (at R3) and acetyltransferase (at K5, K8, K12 and K16) family assays and for screening small molecular inhibitors of Histone 4 (R3) methyltransferases for drug discovery.
Reference(s):

Application Reference(s):
1. Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013)
2. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury (2013)

Warning(s):
Avoid freeze/thaw cycles.
Amino Acid Sequence:
SGRGKGGKGLGKGGAKRHRKV
Scientific Category:
Methyltransferase
Product Type:
Substrate
Data shown is lot-specific. Contact us for specific information on other lots.

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