| 产品名称 | WDR5, His-tag - Enzymes - Methyltransferase(s) |
| 产品货号 | 71200 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 37.5 kDa
Genbank #: NM_017588
Tag(s): N-terminal His-tag
a.a: 2–334(end)
Background: As part of the MLL1/MLL complex, WDR5 is involved in methylation and dimethylation at Lys4 of histone H3, which is a specific tag for epigenetic transcriptional activation. As part of the NSL complex, it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. WDR5 may regulate osteoblasts differentiation. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes WDR5 contains 7 WD repeats.
Description: Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
UniProt P61964
Synonym(s): WDR5, WD Repeat Domain 5, SWD3, BIG-3, Set1c WD40 Repeat Protein, BMP2-Induced 3-Kb Gene Protein
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Trievel, R.C., Shilatifard, A. (2009). Nature Struct. Mol. Biol. 16 (7): 678-80.
2. Wang, Y.Y., et al. (2010). Proc. Natl. Acad. Sci. USA 107(2):815-20. 3. Odho, Z., et al. (2010). J. Biol. Chem. 285(43):32967-76 Warning(s): Avoid freeze/thaw cycles
Scientific Category: Methyltransferase
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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