| 产品名称 | PRMT7, His-FLAG-tag - Enzymes - Methyltransferase(s) |
| 产品货号 | 51054 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 20 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 80 kDa
Genbank #: NM_019023,
Tag(s): N-terminal His-FLAG-tag
a.a: 2–692(end)
Background: Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer
Description: Human PRMT7 (protein arginine methyltransferase 7), GenBank Accession No. NM_019023, a.a. 2-692(end) with N-terminal His-FLAG-tag, MW=80 kDa, expressed in Sf9 cells using a Baculovirus expression system.
UniProt Q9NVM4
Synonym(s): protein arginine N-methyltransferase 7, PRMT7, Histone-arginine N-methyltransferase7
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 µg/ml FLAG peptide, 3 mM DTT, 20% glycerol
Format: Aqueous buffer solution
Storage / Stability: At least 6 months at -80°C.
Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Miranda, T.B., et al. J. Biol. Chem. 2004 May 28,279(22):22902-7
2. Lee, J.H., et al. J. Biol. Chem. 2005 Feb 4,280(5):3656-64. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Methyltransferase
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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