Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal FLAGtag, MW=37 kDa, expressed in a baculovirus-infected Sf9 insect expression system.

P61964

WD Repeat Domain 5, SWD3, BIG-3, Set1c WD40 Repeat Protein, BMP2-Induced 3-Kb Gene Protein

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween- 20, 20% glycerol, 80 μg/ml FLAG peptide

Aqueous buffer solution

At least 6 months at -80°C

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

1. Trievel, R.C., Shilatifard, A. Nature Struct. Mol. Biol. (2009). 16 (7): 678-80.
2. Wang, Y.Y., et al.  Proc. Natl. Acad. Sci. (2010). USA 107(2):815-20.
3. Odho, Z., et al.  J. Biol. Chem. (2010) .285(43):32967-76.

Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended.

Methyltransferase

Enzyme