UNC0638 is a selective inhibitor of G9a and G9a-like protein (GLP), also known as EHMT1, with IC50's in the very low (<20) nM range. It also exhibits very weak activity against JMJD2E (IC50 ~4.5 µM), but the selectivity for G9a and GLP is over 200-fold. UNC0638 was inactive against SUV39H1, SUV39H2, EZH2), SETD7, MLL, SMYD3, DOT1L, SETD8, PRDM1, PRMT1 and PRMT3. UNC0638 exhibits only extremely weak inhibition of DNMT1 (IC50 >100 µM).
| 产品名称 | UNC0638 |
| 产品货号 | 27222 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 5 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 509.7 Da
CAS Registry #: 1255580-76-7
Formula: C30H47N5O2
Description: Purity: ≥98% by HPLC Biological Activity: UNC0638 inhibits G9a activity with an IC50 value of <15 nM in vitro. It also inhibits GLP with an IC50 value of 19 nM.
Solubility: Soluble in DMSO purged with an inert gas, then dilute into aqueous buffer just
before use. Solubility in DMSO is 20 mg/ml.
Format: A crystalline solid.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Tachibana, M., et al., Genes Dev. 2002; 16:1779-1791.
2. Wagschal, A., et al., Mol. Cell. Biol. 2008; 28(3):1104-1113. 3. Thomas, L.R., et al., J. Immunol. 2008; 181:485-493. Scientific Category: Methyltransferase
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
