Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase.

KY 12420

≥99%

Soluble in DMSO (50mg/ml), methanol (5mg/ml) or 100% ethanol (25mg/ml). Very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM.

White to off-white solid.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Wymann, M.P. et al.; (1996). Mol. Cell. Biol. 16, 1722.
2. M. Ui, et al. (1995). TIBS 20, 303.
3. Arcaro, A. and Wyman, M.P. (1993). Biochem. J. 296, 297.

Kinase

Inhibitor