| 产品名称 | SGI-1776 free base - Kinase Inhibitors - Kinase(s) |
| 产品货号 | 27651-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 405.4 Da
CAS Registry #: 1025065-69-3
Formula: C20H22F3N5O
Target: Pim1
Background: According to preliminary results from studies treating prostate cancer cells, SGI-1776 dose-dependently reduces phosphorylation of known Pim kinase substrates involved in cell cycle progression and apotosis (p21Cip1/WAF1 and Bad), compromises overall cell viability by inducing G1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (MDR1) protein based taxane-refractory prostate cancer cell line.
Description: SGI-1776 is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. Treatment with SGI-1776 induces apoptosis in CLL primary cell line.
Synonym(s): N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
Purity: ≥98% by HPLC Biological Activity: SGI-1776 inhibits Pim1, Pim2, Pim3, and FLT3 with IC50 values of 7 nM, 363 nM, 69 nM, and 44nM respectively.
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Mumenthaler, SM., et al. Mol Cancer Ther. 2009; 8(10): 2882-2893.
2. Lisa S. Chen, LS et al. Blood. 2009; 114(19): 4150-4157. Scientific Category: Kinase Inhibitors
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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