| 产品名称 | ROCK2, GST-tag - Serine-Threonine Kinases - Kinase(s) |
| 产品货号 | 40086 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 88 kDa
Genbank #: NM_004850
Tag(s): N-terminal GST-tag
a.a: 5–554
Background: ROCK2 is a ubiquitously expressed serine/threonine kinase localized in the nucleus that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element (1). ROCK2 is an immediate downstream target of the small GTPase RhoA. ROCK2 may play a pivotal role in cardiovascular diseases such as vasospastic angina, ischemic stroke, and heart failure. Inhibition of ROCKs by statins or other selective inhibitors leads to the upregulation and activation of endothelial nitric oxide synthase (eNOS) and reduction of vascular inflammation and atherosclerosis (2).
Description: Recombinant human ROCK2 (a.a. 5-554) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_004850.
Synonym(s): KIAA0619, ROCK-II, ROKalpha
Purity: ≥90%
Specific Activity: 350 pmol/min/µg
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Zhao, Y M. et al. Dev Biol. 2004 Nov 1;275(1):183-91.
2. Noma, K. et al. Am J Physiol Cell Physiol. 2006 Mar;290(3):C661-8. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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