| 产品名称 | PIM2, GST-tag - Serine-Threonine Kinases - Kinase(s) |
| 产品货号 | 40153 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 61 kDa
Genbank #: NM_006875
Tag(s): N-terminal GST-tag
a.a: full length
Background: PIM2 is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon (1). It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells as well as during meiosis. Similar to PIM1, PIM2 also acts as a pro-survival kinase and BAD protein is a legitimate PIM2 substrate (2).
Description: Recombinant human PIM2, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
Synonym(s): PIM-2
Purity: ≥75%
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Baytel, D. et al. Biochim. Biophys. Acta 1442: 274-285, 1998.
2. Yan, B. et al. J Biol Chem. 2003 Nov 14;278(46):45358-67. 3. Neri P, Bahlis NJ. Blood. 2013 Aug 29;122(9):1534-6. 4. Blanco-Aparicio C, Carnero A. Biochem Pharmacol. 2013 Mar 1;85(5):629-43. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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