| 产品名称 | NDR, GST-tag - Serine-Threonine Kinases - Kinase(s) |
| 产品货号 | 40138 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 81 kDa
Genbank #: NM_007271
Tag(s): N-terminal GST-tag
a.a: full length
Background: NDR or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins (1). Fas and TNFα receptor stimulation activates human NDR by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade (2). NDR is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. NDR is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. NDR-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.
Description: Recombinant human NDR, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
Synonym(s): NDR1, STK38
Purity: ≥75%
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Millward, T. et.al: Molecular cloning and characterization of a conserved nuclear serine (threonine) protein kinase. Proc. Nat. Acad. Sci. 92: 5022-5026, 1995.
2. Vichalkovski A. et al: NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol. 2008 Dec 9;18(23):1889-95. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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