| 产品名称 | Mouse MEK1 (EE), GST-tag - Serine-Threonine Kinases - Kinase(s) |
| 产品货号 | 40121 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Mouse
Host Species: E. coli
MW: 69 kDa
Genbank #: NM_008927
Tag(s): N-terminal GST-tag
a.a: full length
Background: MEK1 (EE) is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (1). Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer (2).
Description: Recombinant mouse MEK1 (S218E, S222E), full length with Serine to Glutamic acid mutations on a.a. 218 and 222 and an N-terminal GST-tag, expressed in E. coli cells.
Synonym(s): MAP2K1; MKK1; MAPKK1; PRKMK1; mitogen activated protein kinase kinase
Purity: ≥95%
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Seger, R. et al: The MAPK signaling cascade. FASEB J. 9: 726-735, 1995.
2. Sebolt-Leopold, J S. et al: Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Med. 5: 810-816, 1999. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Dual
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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