| 产品名称 | LRRK2 (R1441H), GST-Tag - Serine-Threonine Kinases - Kinase(s) |
| 产品货号 | 40837 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 210 kDa
Genbank #: NM_198578
Tag(s): N-terminal GST tag
a.a: 968-end
Background: LRRK2 or leucine-rich repeat kinase is a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. Mutations in LRRK2 are the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease with prevalent mutations being found within the GTPase and kinase domains (1). LRRK2 cooperates with MET to promote efficient tumor cell growth and survival in various cancers. Down-regulation of LRRK2 in cultured tumor cells compromises MET activation and selectively reduces downstream MET signaling to mTOR and STAT3 (2).
Description: Human LRRK2 protein with a R1441H mutation, also known as PARK8, RIPK7, and ROCO2, GenBank Accession No. NM_198578, amino acids 968-end, with an N-terminal GST-tag, expressed in an SF9cell expression system. MW = 210 kDa.
Synonym(s): PARK8; RIPK7; ROCO2; AURA17; DARDARIN
Specific Activity: ≥ 21 pmol/min/µg
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Storage / Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application(s): Kinase Assay
Reference(s): 1. Yao C., et al., Neurobiol Dis. 2010 Oct;40(1):73-81.
2. Looyenga B., Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1439-44 Scientific Category: Kinase
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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