| 产品名称 | TPM3-TRKA Mutant, GST-Tag |
| 产品货号 | 79080 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 μg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 125 kDa
Genbank #: TPM3: NM_152263, TRKA: NM_002529
Tag(s): N-Terminal GST-Tag
a.a: TPM3: 1-258, TRKA: 399-end
Background: TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans. The oncogenic rearrangement of 5′TPM3-3′NTRK1 fusion gene has been found in papillary thyroid carcinomas.
Description: Human TPM3-TRKA fusion protein, TPM3 GenBank Accession No. NM_152263, a.a. 1-258, TRKA Genbank Accession No. NM_002529, a.a. 399-end, expressed in an E. coli expression system. TMP3-TRKA MW = 105 kDa.
Synonym(s): TRKA, TPM3, TPM3 TRKA mutant, NTKR
Formulation: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Storage / Stability: Store product at –80°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application(s): Kinase Assay
Reference(s): 1. Smeyne, R. J. et.al: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246-249, 1994.
2. Marta G. B. et.al: A Sequence Analysis of the Genomic Regions Involved in the Rearrangements between TPM3 and NTRK1 Genes Producing TRK Oncogenes in Papillary Thyroid Carcinomas. Genomics, Volume 28, Issue 1, 1 July 1995, Pages 15–24 Scientific Category: Kinase
Product Type: Receptor Tyrosine
Data shown is lot-specific. Contact us for specific information on other lots.
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