| 产品名称 | PLK3 Polo Box Domain, MBP-tag, His-tag - Kinase(s) |
| 产品货号 | 50302 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 80.5 kDa
Genbank #: NM_004073
Tag(s): N-terminal MBP-tag, C-terminal His-tag
a.a: 335–646
Background: PLK3 or Polo-like kinase 3 is a cytokine-inducible kinase that is a member of the Polo family of serine/threonine protein kinases. PLK3 contains both a catalytic domain and a putative regulatory domain and plays an important role in the regulation of cell cycle progression and tumorigenesis. PLK3 is closely associated with centrosomes in several human cell lines and its localization is dependent on the integrity of microtubules. Hence, PLK3 is also involved in regulating microtubule dynamics and centrosomal function.
Description: Human N-terminal MBP tagged Plk3 polo box domain (GenBank Accession No.NM_004073/NP_004064), a.a. 335-646 with C-terminal His-tag, MW=80.5 kDa, expressed in an E. coli expression system.
UniProt Q9H4B4
Synonym(s): CNK, FNK, PRK, polo-like kinase 3
Formulation: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 10% glycerol, 225 mM imidazole, and 3 mM DTT.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Li, Z., et al., J. Biol. Chem. 280 (17), 16843-16850 (2005).
2.Xie,S., et al., Oncogene 23 (21), 3822-3829 (2004). Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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