| 产品名称 | PKC ι/λ, GST-tag |
| 产品货号 | 40015 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 93 kDa
Genbank #: NM_002740
Tag(s): N-terminal GST-tag
a.a: 2–587
Background: PKCι (PKC iota) is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKCι showed greatest homology to PKCζ (PCKzeta), with 72% identity overall rising to 84% in the catalytic domain. Protein kinase Cι (PKCiota) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKCι in the colon are highly susceptible to carcinogen-induced colon carcinogenesis.
Description: Human PKC iota (PCKι), also known as PKClambda (PKCλ), GenBank Accession No. NM_002740, a.a. 2-587 with N-terminal GST-tag, expressed in a Baculovirus infected Sf9 cell expression system. MW= 93 kDa.
Synonym(s): Protein Kinase C Iota, PCKi, PKClambda, Protein Kinase C Lambda, PCKl, PKCι, PKCλ
Formulation: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 3mM DTT and 50% glycerol.
Format: Aqueous buffer solution
Storage / Stability: At least 6 months at -80°C.
Reference(s): 1. Zhang, J. et al., J. Biol. Chem. 279, 22118- 22123 (2004).
2. Gustrafson, W.C. et al., J. Biol. Chem. 279, 9400-9408 (2004). Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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