| 产品名称 | PDGFRa, Mouse, GST-tag |
| 产品货号 | 40260 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Mouse
Host Species: Sf9 insect cells
MW: 100 kDa
Genbank #: NM_011058
Tag(s): N-terminal GST-tag
a.a: 550–end
Background: PDGFRα (platelet-derived growth factor receptor α) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes (1). PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase (2).
Description: Recombinant mouse PDGFRalpha (550-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_011058.
Synonym(s): CD140a, Pdgfr-2, AI115593
Purity: ≥90%
Specific Activity: 14 pmol/min/µg
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Floege, J. et al. J Am Soc Nephrol. 1998 Feb,9(2):211-23.
2. Kumagai, S. et al. Tohoku J Exp Med. 2001 Sep,195(1):21-33. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Receptor Tyrosine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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