| 产品名称 | MEK1, GST-tag |
| 产品货号 | 40123 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 72 kDa
Genbank #: NM_002755
Tag(s): N-terminal GST-tag
a.a: full length
Background: MEK1 is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (1). Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer (2).
Description: Recombinant human MEK1, also known as MAP2K1 (MAP [Mitogen-Activated Protein] Kinase Kinase 1), MKK1, or ERK kinase, GenBank Accession #NM_002755, full length, with an N-terminal GST-tag, MW = 74 kDa, expressed in Sf9 cells via a baculovirus expression system.
Synonym(s): MAP2K1; MKK1; MAPKK1; PRKMK1
Purity: ≥95%
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Sebolt-Leopold., J.S., et al. Nature Med. 5:810-816 (1999).
2. Seger, R., et al. FASEB J. 9:726-735 (1995). Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Dual
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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