| 产品名称 | FRK, GST-tag |
| 产品货号 | 40424 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 60 kDa
Genbank #: NM_002031
Tag(s): N-terminal GST-tag
a.a: 208–end
Background: FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in beta-cells from the pancreas increases the susceptibility of these cells to beta-cell-toxic events (hallmark of Type I diabetes)(2).
Description: Recombinant human FRK (208-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_002031.
Synonym(s): GTK, RAK, PTK5
Specific Activity: 997 pmol/min/µg
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Craven, R J. et al. Cancer Res. 1995 Sep 15,55(18):3969-72.
2. Welsh, M. et al. Biochem J. 2004 Aug 15,382(Pt 1):261-8. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Cytoplasmic Tyr
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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