| 产品名称 | EIF2AK3, GST-tag |
| 产品货号 | 40059 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 115 kDa
Genbank #: NM_004836
Tag(s): N-terminal GST-tag
a.a: 563–1115
Background: EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) leading to its inactivation and a rapid reduction of translational initiation and repression of global protein synthesis. EIF2AK3 is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins (1). EIF2AK3 plays a major role in the ability of cells to adapt to ER stress and is also involved in an integrated adaptive response to hypoxic stress in HeLa cells (2). EIF2AK3 functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia.
Description: Recombinant human EIF2AK3 (a.a. 563-1115), with N-terminal GST-tag, expressed in E. coli cells
Synonym(s): PERK, PEK, WRS, HRI, DKFZp781H1925, double-stranded RNA-activated protein kinase
Purity: ≥90%
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Harding, H. P. et.al: EIF2AK3 is essential for translational regulation and cell survival during the unfolded protein response. Molec. Cell 5: 897-904, 2000.
2. Blais, J. D. et.al: Activating transcription factor 4 is translationally regulated by hypoxic stress. Molec. Cell. Biol. 24: 7469-7482, 2004. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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