CK1ε is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CK1ε is a regulator of Yes-associated protein (YAP) transcription coactivator which is a key regulator of organ size and a candidate human oncogene. CK1ε is activated by CCK2R and this then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells (1). CKIε can phosphorylate topoisomerase (topo) IIalpha at serine-1106 and this regulates the enzyme activity and sensitivity to topo II-targeted drugs (2).
| 产品名称 | CK1 epsilon, GST-Tag |
| 产品货号 | 79349 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 μg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 72kDa
Genbank #: NM_001894
Tag(s): GST-Tag
Background: Description: Full length recombinant human CK1ε, also known as CSNK1E, HCKIE, MGC10398, and CK1E. Genbank Accession NM_001894 N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 72kDa.
Synonym(s): CSNK1E, HCKIE, MGC10398, CK1E
Purity: ≥70%
Formulation: 50mM Tris-HCL, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Storage / Stability: At least 6 months at –80°C. Avoid freeze/thaw cycles.
Application(s): Useful for the kinase assay kits and western blotting.
Reference(s): 1. von Blume, J., et al., EMBO J 2007;26(22):4619-33. Scientific Category: Kinase
Product Type: Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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