| 产品名称 | CDK7/CyclinH1/MNAT1, His-tags |
| 产品货号 | 40098 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 40 kDa (CDK7), 39 kDa (Cyclin H1), 37 kDa (MNAT1)
Genbank #: NM_001799, NM_001239, NM_002431
Tag(s): N-terminal His-tag (CDK7 and MNAT1), C-terminal His-tag (CyclinH1)
a.a: full length
Background: CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).
Description: Complex of recombinant human CDK7 (a.a. 2-346 [end]), Cyclin H1 (a.a. 1-323 [end]), and MNAT1 (a.a. 2-309 [end]) with N-terminal His-tags (CDK7 and MNAT1) and C-terminal His-tag (CyclinH1), GenBank Accession Nos. NM_001799, NM_001239, and NM_002431 respectively, co-expressed in Sf9 insect cells via a baculovirus expression system.
Synonym(s): Cyclin-Dependent Kinase 7, CAK1, STK1, CDKN7, p39MO15
Cyclin H1: CCNH, CAK, p34, p37 MNATI: MAT1, RNF66 Purity: ≥80%
Specific Activity: 21 pmol/min/µg
Assay Conditions: Inhibition of CDK7/Cyclin H/MAT1 enzyme by Dinaciclib, measured using the CDK7 assay kit (Cat. #79603). Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween20, 20% glycerol, and 226mM imidazole
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Fisher, R. P.;A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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