| 产品名称 | Wnt-C59 - Other - Inhibitors / Activators |
| 产品货号 | 27780-3 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 5 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 379.5 Da
CAS Registry #: 1243243-89-1
Formula: C25H21N3O
Target: Porcupine
Background: Wnt-C59 prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity, similar to Wnt inhibitors IWP-2, IWP-3 and IWP-4. But Wnt-C59 is more potent and selective, and has better chemical/physical properties, and is more suitable for in vitro/in vivo studies.
Description: Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
Synonym(s): 2-[4-(2-Methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): Proffitt KD, et al. Cancer Res. 2013 Jan 15;73(2):502-7.
Scientific Category: Wnt Signaling
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
Quality Assurance
|
| 产品资料 |
