Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction.

≥93% by HPLC

400 µM solution in anhydrous DMSO

Novobiocin has been shown to inhibit bacterial DNA gyrase supercoiling with an IC50 of 0.08 µM

A red aqueous solution

Store at or below –20°C and avoid multiple freeze-thaw cycles to prevent decomposition.

1. Lamour V, et al., J Biol Chem. 2002 May 24;277(21):18947-53.
2. Alt, S., et al., J Antimicrob Chemother. 2011 Jun 11; doi:10.1093/jac/dkr247.

Avoid freeze/thaw cycles.

Miscellaneous

Inhibitor