Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM).

Rapamune, Sirolimus

≥99%

Soluble in DMSO at 200 mg/ml; soluble in ethanol at 50 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM.

Off-white or yellow solid.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Terada, N., et al. J. Biol. Chem. 268: 12062-12068 (1993).

Kinase

Inhibitor