K252a is a general kinase inhibitor that inhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), PKG (Ki = 20 nM), CaMK (Ki = 1.8 nM), and phosphorylase kinase (IC50 = 1.7 nM). It functions by acting competitively with ATP and noncompetitively with the substrate.

≥99%

Soluble in DMSO at 100 mg/ml; poorly soluble in ethanol. 

White to pale yellow powder.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Kase, H., et al. Biochem. Biophys. Res. Commun. 142: 436-440 (1987).
2. Hashimoto, Y., et al. Biochem. Biophys. Res. Commun. 181: 423-429 (1991).

Kinase

Inhibitor