Axitinib (AG-013736) is an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), platelet derived growth factor receptor (PDGFR), and cKIT (CD117).

AG-013736

≥99%

Soluble in DMSO at 33 mg/ml; soluble in ethanol at 1.7 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM.

White to off-white solid

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Mancuso, M.R., et al. J. Clin. Invest. 116: 2610-2621 (2006).

Kinase

Inhibitor