| 产品名称 | Recombinant Histone Octamer (Human) |
| 产品货号 | 52037 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 μg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 116 kDa
Genbank #: NM_033445, NM_003528, NM_003532, NM_003548
Tag(s): N-terminal His-tag
Background: The histone octamer is composed of a central heterotetramer of two copies of both histones H3 and H4, flanked by two heterodimers of histones H2A and H2B. The octamer assembles when the H3/H4 tetramer complexes with two H2A/H2B dimers. These histones of the histone octamer all contain N-terminal tails that emanate from their central histone folds and are targets for epigenetic modification.
Description: Human recombinant histone octamer consisting of 2 molecules each of histones H2A (a.a. 2-130(end)), H2B (a.a. 2-126(end)), H3 (a.a. 2-137(end)), and H4 (a.a. 2-103(end)), expressed in an E. coli expression system. GenBank Accession Nos. are NM_033445, NM_003528, NM_003532, and NM_003548, respectively. Each histone protein has an N-terminal His-tag. Global MW = 113.8 kDa.
UniProt Q7L7L0, Q16778, P68431, P62805
Formulation: 10 mM Tris pH 7.4, 2 M NaCl, 1 mM EDTA, 5 mM BME, and 10% glycerol
Format: Aqueous buffer solution
Storage / Stability: Stable at -80°C for at least 6 months from date of receipt, when stored as directed
Application(s): Substrate for histone methyltransferase or acetyltransferase assays. Ideal for screening small molecular inhibitors of histone methyltransferases and acetyltransferases for drug discovery and HTS applications. Since the recombinant histone proteins in thi
Reference(s): 1. Miller KM, Jackson SP. Biochem Soc Trans 40(2):370-6 (2012). Warning(s): Avoid freeze/thaw cycles
Scientific Category: Methyltransferase
Product Type: Substrate
Data shown is lot-specific. Contact us for specific information on other lots.
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