| 产品名称 | Histone H3/H4 Tetramer (full length), His-tag |
| 产品货号 | 52064-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 57 kDa
Genbank #: NM_003532, NM_003548
Tag(s): N-terminal His-tag
Background: The histone tetramer consists of two copies of both histones H3 and H4. It forms the central core of the nucleosome and, as such, plays a prominent role in the assembly, disassembly and positioning of nucleosomes.
Description: Human recombinant histone tetramer, full length, consisting of 2 molecules each of histones H3 (a.a. 1-136(end)), and H4 (a.a. 1-103(end)), each with an N-terminal His-tag, expressed in an E. coli expression system. GenBank Accession Nos. are NM_003532, and NM_003548, respectively. Global MW = 57 kDa.
UniProt P68431, P62805
Synonym(s): H3/H4
Formulation: 45 mM Tris pH 7.5, 2 M NaCl, 1 mM EDTA, 1 mM DTT and 10% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at –80°C Application(s): Substrate for histone methyltransferase or acetyltransferase assays. Ideal for screening small molecular inhibitors of histone methyltransferases and acetyltransferases for drug discovery and HTS applications.
Reference(s): 1. Huang, C., et al., PLoS Genet. 2013; 9(6): 1371. Notes: Since the recombinant histone proteins in this tetramer were prepared in E. coli, they will not have methyl, acetyl or many other epigenetic marks.
Warning(s): Avoid freeze/thaw cycles
Scientific Category: Methyltransferase
Product Type: Substrate
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
