Valproic acid inhibits histone deacetylases (HDACs), in particular Class I HDACs. It is an analog of the natural fatty acid valeric acid. Valproic acid also inhibits GSK3 and depletes cellular inositol-1,4,5-triphosphate. It can have strong effects on stem cell differentiation and self-renewal, and it shows promise in treating cancer and Alzheimer’s disease.
| 产品名称 | Valproic Acid - Inhibitors / Activators - Deacetylase(s) |
| 产品货号 | 27207 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 g |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 167.2 Da
CAS Registry #: 1069-66-5
Formula: C8H16O2 Na
Description: Purity: ≥95% by HPLC Biological Activity: Valproic acid inhibits Class I HDACs with an IC50 of ~ 2 mM.
Solubility: Soluble in ethanol, DMSO and dimethyl formamide (DMF). Solubility in ethanol is 30 mg/ml and 5 mg/ml in DMSO and DMF. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers.
Format: A crystalline solid.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Jung, G., et al., BMC Cell Biol. 2008; 9(66).
2. Bug, G., et al., Cancer Res. 2005; 65(7): 2537 – 2541. 3. Gottlicher, M., et al., EMBO J. 2001; 20(24): 6969 – 6978. Scientific Category: HDAC
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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