| 产品名称 | Tenovin-1 - Inhibitors / Activators - Deacetylase(s) |
| 产品货号 | 27660-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 369.5 Da
CAS Registry #: 380315-80-0
Formula: C20H23N3O2S
Target: SIRT1, SIRT2
Background: Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. Tenovin-1 also exerts inhibition against human sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2), two important members of the sirtuin family. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. An improved and water-soluble version of tenovin-1 has been found to decrease the peptide deacetylase activity of human SIRT1 and SIRT2 with IC50 values of 21 µM and 10 µM respectively.
Description: Tenovin-1 inhibits the protein-deacetylating activities of SIRT1 and SIRT2. Tenovin-1 is also a p53 activator and elevates the amount of p53 protein within 2 hr of treatment, without altering p53 mRNA levels. Tenovin-1 protects against MDM2-mediated p53 degradation via ubiquitination.
Synonym(s): N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
Purity: ≥99% by HPLC Solubility: Soluble in DMSO 74 mg/ml (200 mM), or 15% Captisol (modified cyclodextrin) 15 mg/ml. Solubility in water or ethanol is < 1 mg/ml (< 1 mM)
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): Lain S, et al. Cancer Cell. 2008 May;13(5):454-63.
Scientific Category: Deacetylase Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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